Journal
TRANSCRIPTION-AUSTIN
Volume 5, Issue 1, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/trns.27050
Keywords
RNA polymerase II; preinitiation complex; general transcription factors; TBP; TFIIB; TFIIF; TFIIE; TFIIH
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The general transcription factors required for the assembly of the RNA polymerase II preinitiation complex at TATA-dependent promoters are well known. However, recent studies point to two quite distinct pathways for assembly of these components into functional transcription complexes. In this review, the two pathways are compared and potential implications for gene regulatory mechanisms are discussed.
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