Journal
BMC CANCER
Volume 14, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1471-2407-14-932
Keywords
Long non-coding RNA; Tumor suppressor; Gastric carcinoma; Epithelial-to-mesenchymal transition
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Funding
- Zhejiang Provincial Natural Science Foundation of China [LQ12H16009]
- Science and Technology Bureau of Zhejiang Province [2013C33137]
- Science and Technology Project of the health department of Zhejiang Province [2008A092]
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Background: Long non-coding RNAs have been shown to have critical regulatory roles in cancer biology. However, the contributions of lncRNAs to gastric cancer remain largely unknown. Methods: The differential expression of lncRNAs in gastric cancer and paired non-cancerous tissues were identified by microarray and validated using quantitative real-time PCR. Gastric samples from patients with gastric cancer were further analyzed for levels of a specifically downregulated lncRNA (termed as LEIGC). Results: We found that there were significantly lower levels of LEIGC expression in cancer tissue than in adjacent non-cancerous tissues in human gastric cancers (P < 0.01). Overexpression of LEIGC suppressed tumor growth and cell proliferation, and enhanced the sensitivity of gastric cancer cells to 5-fluorouracil (5-FU), whereas knockdown of LEIGC showed the opposite effect. We further demonstrated LEIGC functions by inhibiting the epithelial-tomesenchymal transition (EMT) in gastric cancer. Conclusions: Our data suggested that LEIGC is a tumor-suppressing lncRNA in gastric cancer, and led us to propose that lncRNAs may play important regulatory roles in cancer development and progression.
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