4.6 Article

CYP1A1 gene polymorphisms increase lung cancer risk in a high-incidence region of Spain: a case control study

Journal

BMC CANCER
Volume 10, Issue -, Pages -

Publisher

BMC
DOI: 10.1186/1471-2407-10-463

Keywords

-

Categories

Funding

  1. Junta de Extremadura, Consejeria de Economia, Comercio e Innovacion, Merida (Spain) [PRI08A008, GRU08120]
  2. Junta de Extremadura, Consejeria de Sanidad y Consumo [SCSS0750]
  3. Plan Nacional de Investigacion Cientifica [PI071152, 00/003401-02]

Ask authors/readers for more resources

Background: A rural region in south-west Spain has one of the highest lung cancer incidence rates of the country, as revealed by a previous epidemiological 10-year follow-up study. The present work was undertaken to ascertain the role of CYP1A1 gene polymorphisms and their interaction with tobacco smoking in the development of the disease in this location. Methods: One-hundred-and-three cases of lung cancer and 265 controls participated in the study. The participants were screened for the presence of four CYP1A1 polymorphisms, namely MspI, Ile462Val, T3205C, and Thr461Asn. Lung cancer risk was estimated as odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression models adjusting for age, sex, and smoking. Results: The distribution of the variant CYP1A1 alleles was different from that described for other Caucasian populations, with CYP1A1*2A showing an uncommonly high frequency (p < 0.01). The CYP1A1*2B allele (carrying MspI and Ile462Val mutations) was strongly associated with high lung cancer risk (OR = 4.59, CI: 1.4-12.6, p < 0.01). The Ile462Val polymorphism was also shown to increase the risk for the disease (OR = 4.51, CI: 1.8-11.9; p < 0.01) and particularly for squamous-cell (OR = 5.01; CI: 1.6-14.3, p < 0.01) and small-cell lung carcinoma (SCLC) (OR = 6.97, CI: 1.2-81.3; p = 0.04). Moreover, the Thr461Asn polymorphism was found to be associated with SCLC in a Caucasian population for the first time to our knowledge (OR = 8.33, CI: 1.3-15.2, p = 0.04). Conclusion: The results suggest that CYP1A1 polymorphisms contribute to increase lung cancer susceptibility in an area with an uncommon high incidence rate.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available