Journal
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
Volume 65, Issue 1, Pages 27-32Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAI.0b013e3182a990e2
Keywords
single nucleotide polymorphism; ACSM4; LTNPs; rapid progressors; NEMP
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Funding
- Instituto de Salud Carlos III, Spanish Healt Ministry [RD06/0006/0035]
- Fundacion para la investigacion y prevencion del SIDA en Espana
- Instituto de Salud Carlos III through the Red Tematica de Investigacion Cooperativa en SIDA [RIS C03/173]
- FIC NIH HHS [D43 TW000010, D43TW000010-21S1] Funding Source: Medline
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Our aim was to explore the association among ACSM4 and PECI polymorphisms and AIDS progression in 454 HIV-infected patients never treated with antiretroviral drugs (146 long-term nonprogressors, 228 moderate progressors, and 80 rapid progressors). For ACSM4 polymorphisms, rs7137120 AA/AG and rs7961991 CC/CT genotypes had higher odds of having a rapid AIDS progression [odds ratio (OR) = 3.21; 95% of confidence interval (95% CI) = 1.26 to 8.16; P = 0.014 and OR = 3.60; 95% CI = 1.38 to 9.36; P = 0.009, respectively]. Additionally, the ACSM4 haplotype integrated for both rs7961991 A and rs7137120 C alleles had higher odds of having a rapid AIDS progression (OR = 2.85; 95% CI = 1.28 to 6.25; P = 0.010). For PECI polymorphisms, no significant associations were found. In conclusion, ACSM4 polymorphisms might play a significant role in AIDS progression.
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