Journal
BMC BIOLOGY
Volume 11, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1741-7007-11-57
Keywords
AIDS; HIV; cell receptors; CD4; CCR5; CXCR4; therapy
Categories
Funding
- UK Medical Research Council
- Bill & Melinda Gates Foundation Collaboration on AIDS Vaccine Discovery
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During 30 years of research on human immunodeficiency virus (HIV), our knowledge of its cellular receptors - CD4, CCR5 and CXCR4 - has illuminated aspects of the pathogenesis of the acquired immune deficiency syndrome (AIDS). Studying how the HIV envelope glycoproteins interact with the receptors led to anti-retroviral drugs based on blocking the docking or fusion of virus to the host cell. Genetic polymorphisms of CCR5 determine resistance to HIV infection and the rate of progression to AIDS. Eliciting neutralizing antibodies to the sites of receptor interaction on HIV glycoproteins is a promising approach to HIV vaccine development.
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