Journal
BMC BIOLOGY
Volume 10, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/1741-7007-10-105
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Funding
- NICHD NIH HHS [R01 HD044750, HD044750] Funding Source: Medline
- NIEHS NIH HHS [ES019259, R21 ES019259] Funding Source: Medline
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [0845775] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [1100515] Funding Source: National Science Foundation
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The dramatic ingression of tissue sheets that accompanies many morphogenetic processes, most notably gastrulation, has been largely attributed to contractile circum-apical actomyosin 'purse-strings' in the infolding cells. Recent studies, however, including one in BMC Biology, expose mechanisms that rely less on actomyosin contractility of purse-string bundles and more on dynamics in the global cortical actomyosin network of the cells. These studies illustrate how punctuated actomyosin contractions and flow of these networks can remodel both epithelial and planarly organized mesenchymal sheets.
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