Journal
BMC BIOINFORMATICS
Volume 15, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12859-014-0354-6
Keywords
Phylogeny reconstruction; Ancestral inference; Genome rearrangement; Maximum likelihood
Categories
Funding
- NSF [IIS 1161586]
- Tianjin University, China
- Swiss National Science Foundation [146708]
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Background: The rapid accumulation of whole-genome data has renewed interest in the study of using gene-order data for phylogenetic analyses and ancestral reconstruction. Current software and web servers typically do not support duplication and loss events along with rearrangements. Results: MLGO (Maximum Likelihood for Gene-Order Analysis) is a web tool for the reconstruction of phylogeny and/or ancestral genomes from gene-order data. MLGO is based on likelihood computation and shows advantages over existing methods in terms of accuracy, scalability and flexibility. Conclusions: To the best of our knowledge, it is the first web tool for analysis of large-scale genomic changes including not only rearrangements but also gene insertions, deletions and duplications. The web tool is available from http://www.geneorder.org/server.php.
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