Journal
NATURE NEUROSCIENCE
Volume 18, Issue 8, Pages 1081-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4053
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Funding
- Canadian Institutes of Health Research [MOP-123307]
- Canada Research Chair Program
- Louise and Alan Edwards Foundation
- Anne and Max Tanenbaum Chair Program
- US National Institutes of Health [R01-DE17794]
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE017794] Funding Source: NIH RePORTER
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A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling is essential for chronic pain hypersensitivity. Using multiple approaches, we found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for females in pain research.
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