Journal
BMC BIOINFORMATICS
Volume 13, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1471-2105-13-324
Keywords
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Categories
Funding
- NIGMS [R01GM087221]
- NCI [R01CA137442]
- EU [260558]
- major research instrumentation grant [0923536]
- American Recovery and Reinvestment Act (ARRA) funds from National Institutes of Health National Human Genome Research Institute [R01 HG005805]
- National Institute of General Medical Sciences [2P50 GM076547]
- Luxembourg Centre for Systems Biomedicine
- University of Luxembourg
- Direct For Biological Sciences
- Div Of Biological Infrastructure [923536] Funding Source: National Science Foundation
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Background: For shotgun mass spectrometry based proteomics the most computationally expensive step is in matching the spectra against an increasingly large database of sequences and their post-translational modifications with known masses. Each mass spectrometer can generate data at an astonishingly high rate, and the scope of what is searched for is continually increasing. Therefore solutions for improving our ability to perform these searches are needed. Results: We present a sequence database search engine that is specifically designed to run efficiently on the Hadoop MapReduce distributed computing framework. The search engine implements the K-score algorithm, generating comparable output for the same input files as the original implementation. The scalability of the system is shown, and the architecture required for the development of such distributed processing is discussed. Conclusion: The software is scalable in its ability to handle a large peptide database, numerous modifications and large numbers of spectra. Performance scales with the number of processors in the cluster, allowing throughput to expand with the available resources.
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