Journal
TOXICOLOGY REPORTS
Volume 2, Issue -, Pages 1111-1116Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.toxrep.2015.07.019
Keywords
NADPH oxidase inhibitor (apocynin); Ischemia/reperfusion (I/R); Renal ischemia/reperfusion injury (RI/RI); SHP-1; Preconditioning
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This study was designed to evaluate whether NADPH oxidase inhibitor (apocynin) preconditioning induces expression of Src homology-2 domain-containing phosphatase-1 (SHP-1) to protect against renal ischemia/reperfusion (I/R) injury (RI/RI) in rats. Rats were pretreated with 50 mg/kg apocynin, then subjected to 45 min ischemia and 24 h reperfusion. The results indicated that apocynin preconditioning improved the recovery of renal function and nitroso-redox balance, reduced oxidative stress injury and inflammation damage, and upregulated expression of SHP-1 as compared to RI/RI group. Therefore our study demonstrated that apocynin preconditioning provided a protection to the kidney against I/R injury in rats partially through inducing expression of SHP-1. (C) 2015 The Authors. Published by Elsevier Ireland Ltd.
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