Journal
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
Volume 13, Issue 9, Pages 975-987Publisher
TAYLOR & FRANCIS INC
DOI: 10.1586/14779072.2015.1074861
Keywords
animal models; doxycycline; embryologic origin; epigenetics; extracellular matrix; genetic susceptibility; inflammation; matrix metalloproteinases; risk factors; smoking
Categories
Funding
- National lnstitutes of Health
- Pennsylvania Universal Research Enhancement Program
- Penn Franklin Technology Development Fund of Pennsylvania
- Geisinger Clinical Research Fund
- American Heart Association
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL045996, R01HL064310] Funding Source: NIH RePORTER
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [U01HG006382] Funding Source: NIH RePORTER
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An aortic aneurysm is a dilatation in which the aortic diameter is >= 3.0 cm. If left untreated, the aortic wall continues to weaken and becomes unable to withstand the forces of the luminal blood pressure resulting in progressive dilatation and rupture, a catastrophic event associated with a mortality of 50-80%. Smoking and positive family history are important risk factors for the development of abdominal aortic aneurysms (AAA). Several genetic risk factors have also been identified. On the histological level, visible hallmarks of AAA pathogenesis include inflammation, smooth muscle cell apoptosis, extracellular matrix degradation and oxidative stress. We expect that large genetic, genomic, epigenetic, proteomic and metabolomic studies will be undertaken by international consortia to identify additional risk factors and biomarkers, and to enhance our understanding of the pathobiology of AAA. Collaboration between different research groups will be important in overcoming the challenges to develop pharmacological treatments for AAA.
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