Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 2, Issue 3, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/23723556.2014.992639
Keywords
reactive oxygen species (ROS); granzyme; apoptosis; cell death
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Funding
- Ambizione grant SNSF [PZ00P3_126710/1]
- ERC starting Grant [ERC-2010StG_20091118]
- Carlos and Elsie de Reuter Foundation and Schmidheiny Foundation
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Reactive oxygen species (ROS) are involved in cell signaling, aging, and death and play a role in carcinogenesis. However, whether ROS are bystanders or active effectors of apoptosis was unclear until recently. New evidence shows that the killer lymphocyte protease granzyme B activates a conserved biochemical pathway centered on respiratory chain disruption to trigger mitocentric ROS-dependent apoptosis.
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