Journal
CHILD DEVELOPMENT
Volume 86, Issue 1, Pages 303-309Publisher
WILEY
DOI: 10.1111/cdev.12270
Keywords
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Categories
Funding
- National Institute of Mental Health [R01MH61285]
- Early Experience, Stress and Neurobehavioral Development Center [P50MH078105]
- [F31MH088111]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P30HD003352] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [P30CA014520] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [P50MH078105, T32MH018951, R01MH061285, F31MH088111, R01MH068858] Funding Source: NIH RePORTER
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Children exposed to extreme stress are at heightened risk for developing mental and physical disorders. However, little is known about mechanisms underlying these associations in humans. An emerging insight is that children's social environments change gene expression, which contributes to biological vulnerabilities for behavioral problems. Epigenetic changes in the glucocorticoid receptor gene, a critical component of stress regulation, were examined in whole blood from 56 children aged 11-14years. Children exposed to physical maltreatment had greater methylation within exon 1(F) in the NR3C1 promoter region of the gene compared to nonmaltreated children, including the putative NGFI-A (nerve growth factor) binding site. These results highlight molecular mechanisms linking childhood stress with biological changes that may lead to mental and physical disorders.
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