Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 2, Issue 4, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/23723548.2014.964625
Keywords
CD300 receptors; apoptotic cells; efferocytosis; phosphatidylserine; professional phagocytes; autoimmune disease
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Funding
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI000964] Funding Source: NIH RePORTER
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Engulfment of apoptotic cells is predominantly executed by phagocytes via the recognition of eat me signals like phosphatidylserine (PS). Various PS-specific receptors exist on phagocytes, including Tyro3, Axl, and MerTK receptor tyrosine kinases (TAMs), T-cell immunoglobulin and mucin domain containing 1 and 4 (TIM1/4), and the newly identified CD300 family. The aim of the present auto-commentary is to highlight recent findings regarding the Cd300lf and Cd300lb receptors and their emerging roles in the development of autoimmune disease.
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