Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 2, Issue 2, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/23723556.2014.974467
Keywords
8q24.21; amplification; breast cancer; copy number gain; HCT116; MYC; MDA-MB-231; PVT1; SK-BR-3; TCGA
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Funding
- Masonic Cancer Center Laboratory start-up funds
- Masonic Scholar Award
- Karen Wyckoff Rein in Sarcoma Fund
- Institute of Prostate and Urologic Cancer, University of Minnesota
- American Cancer Society Research Scholar Grant [RSG-14-074-01-TBG]
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Gain of 8q24, harboring the avian myelocytomatosis viral oncogene homolog (MYC), is a frequent mutation in cancers. Although MYC is the usual suspect in these cancers, the role of other co-gained loci remains mostly unknown. We have recently found that MYC partners with the adjacent long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1), which stabilizes MYC protein and potentiates its activity.
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