Journal
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
Volume 13, Issue 12, Pages 1393-1409Publisher
TAYLOR & FRANCIS INC
DOI: 10.1586/14779072.2015.1103648
Keywords
Arrhythmias; Chagas cardiomyopathy; Chagas disease; heart failure; myocardial fibrosis; nanotechnology; oxidative stress; stem cell therapy; vaccine development
Categories
Funding
- National Institutes of Health [HL094802, HL088230, AI054578, AI107227, HL110900, GM104547, AI098461, HL122866]
- Brazilian National Research Council (CNPq - Bolsa de Produtividade em Pesquisa)
- Foundation for Research Support of Minas Gerais (FAPEMIG - Pesquisador Mineiro)
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R21HL088230, R01HL122866, P01HL110900, R01HL094802] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI054578, R21AI107227, P50AI098461] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R25GM104547] Funding Source: NIH RePORTER
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Over 100 years have elapsed since the discovery of Chagas disease and there is still much to learn regarding pathogenesis and treatment. Although there are antiparasitic drugs available, such as benznidazole and nifurtimox, they are not totally reliable and often toxic. A recently released negative clinical trial with benznidazole in patients with chronic Chagas cardiomyopathy further reinforces the concerns regarding its effectiveness. New drugs and new delivery systems, including those based on nanotechnology, are being sought. Although vaccine development is still in its infancy, the reality of a therapeutic vaccine remains a challenge. New ECG methods may help to recognize patients prone to developing malignant ventricular arrhythmias. The management of heart failure, stroke and arrhythmias also remains a challenge. Although animal experiments have suggested that stem cell based therapy may be therapeutic in the management of heart failure in Chagas cardiomyopathy, clinical trials have not been promising.
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