Journal
BMB REPORTS
Volume 47, Issue 8, Pages 417-423Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2014.47.8.109
Keywords
Argonaute protein; MicroRNA; MicroRNA-directed cleavage
Categories
Funding
- National Research Foundation of Korea (NRF) - Korea government (MEST) [2012R1A2A2A01045528]
- Next-Generation BioGreen 21 Program, Rural Development Administration, Republic of Korea [PJ00820603, PJ00801101]
- National Research Foundation of Korea [2012R1A2A2A01045528] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Rural Development Administration (RDA), Republic of Korea [PJ008206032014] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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MicroRNAs (miRNAs) are a large family of post-transcriptional regulators, which are 21-24 nt in length and play a role in a wide variety of biological processes in eukaryotes. The past few years have seen rapid progress in our understanding of miRNA biogenesis and the mechanism of action, which commonly entails a combination of target degradation and translational repression. The target degradation mediated by Argonaute-catalyzed endonucleolytic cleavage exerts a significant repressive effect on target mRNA expression, particularly during rapid developmental transitions. This review outlines the current understanding of the mechanistic aspects of this important process and discusses several different experimental approaches to identify miRNA cleavage targets.
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