Journal
BMB REPORTS
Volume 45, Issue 8, Pages 470-475Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2012.45.8.022
Keywords
Glioma; H4R3diMe; Posttranslational modification; PRMT1; Tumorgenesis
Categories
Funding
- 973 project [2009CB825403, 2011CBA01104, 2007CB946902, 2011-CB504902]
- National Natural Sciences Foundation of China [30825023, 31071203]
- Program for New Century Excellent Talents in University [NCET-07-0505]
- 111 projects
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Protein arginine methyltransferase 1 (PRMT1), a type-I arginine methyltransferase, has been implicated in diverse cellular events. We have focused on the role of PRMT1 in glioma-genesis. In this study, we showed that PRMT1 expression was up-regulated in glioma tissues and cell lines compared with normal brain tissues. The knock-down of PRMT1 resulted in an arrest in the G1-S phase of the cell cycle, proliferation inhibition and apoptosis induction in four glioma cell lines (T98G, U87MG, U251, and A172). Moreover, an in vivo study confirmed that the tumor growth in nude mouse xenografts was significantly decreased in the RNAi-PRMT1 group. Additionally, we found that the level of the asymmetric dimethylated modification of H4R3, a substrate of PRMT1, was higher in glioma cells than in normal brain tissues and decreased after PRMT1 knock-down. Our data suggest a potential role for PRMT1 as a novel biomarker of and therapeutic target in gliomas. [BMB Reports 2012; 45(8): 470-475]
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