Journal
RSC ADVANCES
Volume 5, Issue 17, Pages 13042-13045Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra16601a
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Funding
- 973 program [2013CB933800]
- National Natural Science Foundation of China [21402216, 21222210, 21321064]
- Chinese Academy of Sciences (100 Talents Program)
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We report a facile method for the quantitative detection of cysteine (Cys), homocysteine (Hcy) and glutathione (GSH) in a mixture. BODIPY-based sensors 1 and 2 are synthesized, and the diverse reactivities of 1 and 2 in the presence of a mixture of biothiols lead to distinct absorption spectra at a specified period of time. With a spectral analysis, we are capable of distinguishing three biothiols and achieving the quantitative determination of Cys, Hcy and GSH in a mixture.
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