Journal
BMB REPORTS
Volume 45, Issue 2, Pages 85-90Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2012.45.2.85
Keywords
Anti-cancer effect; Apoptosis; Caspase-independent apoptosis pathways; Cell membrane penetration; Insect peptide; Leukemia
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Funding
- Next-Generation BioGreen 21 Program [PJ008158]
- Rural Development Administration, Republic of Korea [200902FHT010102002]
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Our previous study demonstrated that CopA3, a disulfide dimer of the coprisin peptide analogue (LLCIALRKK), has antibacterial activity. In this study, we assessed whether CopA3 caused cellular toxicity in various mammalian cell lines. CopA3 selectively caused a marked decrease in cell viability in Jurkat T, U937, and AML-2 cells (human leukemia cells), but was not cytotoxic to Caki or Hela cells. Fragmentation of DNA, a marker of apoptosis, was also confirmed in the leukemia cell lines, but not in the other cells. CopA3-induced apoptosis in leukemia cells was mediated by apoptosis inducing factor (AIF), indicating induction of a caspase-independent signaling pathway. [BMB reports 2012; 45(2): 85-90]
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