Journal
BMB REPORTS
Volume 44, Issue 2, Pages 140-145Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2011.44.2.140
Keywords
Akt; Epinephrine; Go 6983; Platelet aggregation; RO 31-8220
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Funding
- Korea Science and Engineering Foundation [R01-2006-000-10654-0]
- Ministry of Education, Science and Technology, Korea
- National Research Foundation of Korea [R01-2006-000-10654-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Impaired responsiveness of platelets to epinephrine (epi) and other catecholamines (CA) has been reported in approximately 20% of the healthy Korean and Japanese populations. In the present study, platelet aggregation induced by epi was potentiated by RO 31-8220 (RO) or GO 6983 (GO). Phosphorylated Akt (p-Akt) was very low in epi-stimulated PRP from CA-hypo-responders (CA-HY), whereas it was detected in those from CA-good responders (CA-GR). RO and Go increased p-Akt, one of the major downstream effectors of phosphoinositol-3 kinase (PI3K), in epi-stimulated PRP from both groups. Wortmannin, a PI3K inhibitor, attenuated the RO or Go-induced potentiation of p-Akt in epi-stimulated PRP, suggesting positive effects for RO and Go on PI3K. TXA(2) formation was increased by the addition of either RO or GO in epi-stimulated platelets. The present data also suggest that impaired Akt phosphorylation may be responsible for epinephrine hypo-responsiveness of platelets. [BMB reports 2011; 44(2): 140-145]
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