4.4 Article

A novel L-ascorbic acid and peptide conjugate with increased stability and collagen biosynthesis

Journal

BMB REPORTS
Volume 42, Issue 11, Pages 743-746

Publisher

KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2009.42.11.743

Keywords

Cosmeceuticals; L-ascorbic acid; Peptide; Stability; Type 1 collagen

Funding

  1. Ministry of Knowledge Economy [M10200-M06010112]

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L-ascorbic acid (Vitamin C) and peptide are both useful compounds for collagen biosynthesis in cosmeceuticals (cosmetic and pharmaceutical fields). The instability of these compounds, however, limit their application in these industries. In this report, we describe the development of a novel compound, Stabilized Ascorbyl Pentapeptide (SAP), which physically is much more stable than L-ascorbic acid in water. The inhibitory effects of this SAP compound on tyrosinase and melanin synthesis is comparable to that of L-ascorbic acid. Importantly, the SAP compound displays no cytotoxicity at a high concentration (5 mM). The ability of SAP to promote collagen biosynthesis is greater than that of L-ascorbic acid or the KTTKS peptide alone. Considering the in vitro stability and functional effects, our data strongly suggest that the SAP compound is a good candidate not only as a cosmetic ingredient but also as a wound healing agent [BMB reports 2009; 42(11): 743-746]

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