Journal
BLOOD REVIEWS
Volume 27, Issue 1, Pages 1-12Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.blre.2012.10.001
Keywords
Major histocompatibility complex (MHC); HLA; Haplotype; Linkage disequilibrium (LD); Graft-versus-host disease (GVHD); Hematopoietic cell transplantation (HCT); Unrelated donor; Cord blood transplantation; Single nucleotide polymorphism (SNP)
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Funding
- National Institutes of Health, USA [CA100019, CA18029, CA162194, AI069197]
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Graft-versus-host disease (GVHD) is a potentially life-threatening complication of allogeneic hematopoietic cell transplantation. Many genes are presumed to be involved in GVHD, but the best characterized genetic system is that of the human major histocompatibility complex (MHC) located on chromosome 6. Among the hundreds of genes located within the MHC region, the best known and characterized are the classical HLA genes, HLA-A, C, B, DRB1, DQB1, and DPB1. They play a fundamental role in T cell immune responses, and HLA-A, C, and B also function as ligands for the natural killer cell immunoglobulin-like receptors involved in innate immunity. This review highlights the state-of-the art in the field of histocompatibility and immunogenetics of the MHC with respect to genetic risk factors for GVHD. (C) 2012 Elsevier Ltd. All rights reserved.
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