Journal
BLOOD REVIEWS
Volume 24, Issue 4-5, Pages 191-199Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.blre.2010.04.001
Keywords
Arsenic trioxide (As2O3); Acute promyelocytic leukemia (APL); Differentiation; Apoptosis; Reactive oxygen species; Induction and consolidation chemotherapy; Multiple myeloma; T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell leukemia-lymphoma (ATL); Myelodysplastic syndrome (MDS)
Categories
Funding
- NCI NIH HHS [K24 CA111717-05, K24 CA111717, R01 CA100904, R01 CA100904-05] Funding Source: Medline
Ask authors/readers for more resources
Over the last 17 years, clinical trials conducted worldwide have demonstrated the efficacy of arsenic trioxide (As2O3) in the treatment of relapsed acute promyelocytic leukemia (APL). Currently, the role of As2O3 in front-line therapy is under investigation. Recent trials in the US have demonstrated that the addition of As2O3 to standard treatment regimens improves survival outcomes in patients with APL and may allow a reduction in cytotoxic chemotherapy exposure. As2O3 has also shown efficacy in other malignancies, particularly multiple myeloma and myelodysplastic syndromes. Therapeutic doses of As2O3 are well tolerated, with no evidence of long-term toxicity. Adverse events include APL differentiation syndrome, electrocardiographic abnormalities, and mild elevations in liver enzymes. This review highlights trials investigating the role of As2O3 in induction and consolidation for newly diagnosed APL, as well as its role in other hematologic malignancies. The chemistry, mechanisms of action, and clinical side effects of As2O3 are also discussed. (C) 2010 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available