Journal
BLOOD REVIEWS
Volume 23, Issue 3, Pages 95-104Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.blre.2008.08.001
Keywords
Ferritin; Iron
Categories
Funding
- National Institutes of Health [R01DK71892, R37 DK42421]
- American Heart Association
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK042421, R01DK071892, R37DK042412] Funding Source: NIH RePORTER
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Ferritin, a major iron storage protein, is essential to iron homeostasis and is involved in a wide range of physiologic and pathologic processes. In clinical medicine, ferritin is predominantly utilized as a serum marker of total body iron stores. In cases of iron deficiency and overload, serum ferritin serves a critical role in both diagnosis and management. Elevated serum and tissue ferritin are linked to coronary artery disease, malignancy, and poor outcomes following stem cell transplantation. Ferritin is directly implicated in less common but potentially devastating human diseases including sideroblastic anemias, neurodegenerative disorders, and hemophagocytic syndrome. Additionally, recent research describes novel functions of ferritin independent of iron storage. (C) 2008 Elsevier Ltd. All rights reserved.
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