Journal
BLOOD PURIFICATION
Volume 36, Issue 2, Pages 107-111Publisher
KARGER
DOI: 10.1159/000354727
Keywords
Acute renal failure; Continuous venovenous hemofiltration; Rhabdomyolysis; Solute clearance; Myoglobinemia
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Background: Rhabdomyolysis can cause acute kidney injury (AKI). It remains controversial whether or not myoglobin can be removed from the circulation with extracorporeal therapy and decrease the incidence of AKI. Therefore, we examined myoglobin removal in a series of 11 patients with oliguric AKI treated with high-volume hemofiltration. Methods: Patients received prefilter hemofiltration using a polysulphone filter with a molecular size cutoff of 65 kDa and a surface area of 1.7 m(2). Sieving coefficients and myoglobin clearances were calculated at 6, 12, and 24 h after the start of hemofiltration. Results: The mean sieving coefficient was 0.158, and the mean myoglobin clearance was 8.7 ml/min. Conclusion: Despite the use of high-volume hemofiltration, the removal of myoglobin was negligible. In patients with normal renal function, the anticipated amount of extracorporeal removal would not significantly impact renal exposure to myoglobin. (C) 2013 S. Karger AG, Basel
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