Journal
MEDICAL DEVICES-EVIDENCE AND RESEARCH
Volume 8, Issue -, Pages 57-64Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/MDER.S70856
Keywords
nose-to-brain; polymer micelles; cell-penetrating peptide; intranasal administration; nucleic acid
Categories
Funding
- Japan Society for the Promotion of Science (JSPS) [25870767]
- Promotion and Mutual Aid Corporation for Private Schools of Japan
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Recently, the development of effective strategies for enhancing drug delivery to the brain has been a topic of great interest in both clinical and pharmaceutical fields. In this review, we summarize our studies evaluating nose-to-brain delivery of drugs and small interfering ribonucleic acids in combination with cell-penetrating peptide-modified polymer micelles. Our findings show that the use of polymer micelles with surface modification with Tat peptide in the intranasal administration enables the non-invasive delivery of therapeutic agents to the brain by increasing the transfer of the administered drug or small interfering ribonucleic acid to the central nervous system from the nasal cavity.
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