Journal
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
Volume 23, Issue 2, Pages 39-46Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/hmbci-2015-0019
Keywords
cancer; obesity; retinoic acid; retinol binding protein 4
Categories
Funding
- NATIONAL CANCER INSTITUTE [U01CA181770, U54CA116867, R01CA136726, P50CA150964] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK088969] Funding Source: NIH RePORTER
- NCI NIH HHS [U01CA181770, UA54CA116867, R01CA136726, P50CA50964, U54 CA116867, U01 CA181770, P50 CA150964, R01 CA136726] Funding Source: Medline
- NIDDK NIH HHS [R01DK088969, R01 DK088969] Funding Source: Medline
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Retinol binding protein 4 (RBP4) is synthesized in the liver where it binds vitamin A, retinol, and transports it to tissues throughout the body. It has been shown in some studies that the level of circulating RBP4 increases with body mass, and the protein has been implicated as a mediator in the development of insulin resistance and the metabolic disease. Adipose tissue serves as another site of RBP4 synthesis, accounting for its designation as an adipokine. In addition to its function as a transport protein, RBP4 serves as a signaling molecule which, by binding to the membrane receptor STRA6, triggers downstream activation of pro-oncogenic pathways including JAK2/STAT3/5. Taken together, available information suggests the possibility that RBP4 may be a link between obesity and cancer.
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