Journal
BIOMARKER INSIGHTS
Volume 10, Issue -, Pages 25-52Publisher
SAGE PUBLICATIONS LTD
DOI: 10.4137/BMI.S29512
Keywords
microRNA; biomarker; virus; herpesvirus; hepatitis
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Funding
- Division Of Undergraduate Education [1623723] Funding Source: National Science Foundation
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MicroRNAs (miRNAs) are short sequences of noncoding single-stranded RNAs that exhibit inhibitory effects on complementary target mRNAs. Recently, it has been discovered that certain viruses express their own miRNAs, while other viruses activate the transcription of cellular miRNAs for their own benefit. This review summarizes the viral and/or cellular miRNAs that are transcribed during infection, with a focus on the biomarker and therapeutic potential of miRNAs (or their antagomirs). Several human viruses of clinical importance are discussed, namely, herpesviruses, polyomaviruses, hepatitis B virus, hepatitis C virus, human papillomavirus, and human immunodeficiency virus.
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