Journal
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Volume 100, Issue 11, Pages 4264-4271Publisher
ENDOCRINE SOC
DOI: 10.1210/jc.2015-2279
Keywords
-
Categories
Funding
- National Institutes of Health [UL1TR00165, P30DK079626, P30DK056336]
- Biomedical Laboratory Research & Development Service from the VA Office of Research and Development [I01BX002363]
- [R03DK095005]
- [R01NS080850]
- [R01CA136716]
Ask authors/readers for more resources
Context: Phosphorus-based food additives can substantially increase total phosphorus intake per day, but the effect of these additives on endocrine factors regulating bone and mineral metabolism is unclear. Objective: This study aimed to examine the effect of phosphorus additives on markers of bone and mineral metabolism. Design and Setting, and Participants: This was a feeding study of 10 healthy individuals fed a diet providing similar to 1000 mg of phosphorus/d using foods known to be free of phosphorus additives for 1 week (low-additive diet), immediately followed by a diet containing identical food items; however, the foods contained phosphorus additives (additive-enhanced diet). Parallel studies were conducted in animals fed low-(0.2%) and high-(1.8%) phosphorus diets for 5 or 15 weeks. Main Outcome Measures: The changes in markers of mineral metabolism after each diet period were measured. Results: Participants were 32 +/- 8 years old, 30% male, and 70% black. The measured phosphorus content of the additive-enhanced diet was 606 +/- 125 mg higher than the low-additive diet (P < .001). After 1 week of the low-additive diet, consuming the additive-enhanced diet for 1 week significantly increased circulating fibroblast growth factor 23 (FGF23), osteopontin, and osteocalcin concentrations by 23, 10, and 11%, respectively, and decreased mean sclerostin concentrations (P < .05 for all). Similarly, high-phosphorus diets in mice significantly increased blood FGF23, osteopontin and osteocalcin, lowered sclerostin, and decreased bone mineral density (P < .05 for all). Conclusions: The enhanced phosphorus content of processed foods can disturb bone and mineral metabolism in humans. The results of the animal studies suggest that this may compromise bone health.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available