Journal
BLOOD CELLS MOLECULES AND DISEASES
Volume 52, Issue 1, Pages 12-18Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bcmd.2013.08.002
Keywords
Hematopoietic stem cells; DNA damage; Reactive oxygen species; Ataxia-telangiectasia mutated
Categories
Funding
- NIH [R00CA139009, R01DK98263]
- NIH MSTP [T32-GM007288]
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The ability of hematopoietic stem cells (HSCs) to self-renew and differentiate into progenitors is essential for homeostasis of the hematopoietic system. The longevity of HSCs makes them vulnerable to accumulating DNA damage, which may be leukemogenic or result in senescence and cell death. Additionally, the ability of HSCs to self-renew and differentiate allows DNA damage to spread throughout the hematologic system, leaving the organism vulnerable to disease. In this review we discuss cell fate decisions made in the face of DNA damage and other cellular stresses, and the role of reactive oxygen species in the long-term maintenance of HSCs and their DNA damage response. (C) 2013 Elsevier Inc. All rights reserved.
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