Journal
BLOOD CELLS MOLECULES AND DISEASES
Volume 51, Issue 4, Pages 220-225Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bcmd.2013.09.006
Keywords
Yolk sac; Hematopoiesis; Erythro-myeloid progenitors; Embryogenesis
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Funding
- NIDDK NIH HHS [R01 DK060403, R01 DK079361] Funding Source: Medline
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Erythro-myeloid progenitors (EMP) serve as a major source of hematopoiesis in the developing conceptus prior to the formation of a permanent blood system. In this review, we summarize the current knowledge regarding the emergence, fate, and potential of this hematopoietic stem cell (HSC)-independent wave of hematopoietic progenitors, focusing on the murine embryo as a model system. A better understanding of the temporal and spatial control of hematopoietic emergence in the embryo will ultimately improve our ability to derive hematopoietic stem and progenitor cells from embryonic stem cells and induced pluripotent stem cells to serve therapeutic purposes. (C) 2013 Elsevier Inn All rights reserved.
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