Journal
BLOOD CELLS MOLECULES AND DISEASES
Volume 51, Issue 4, Pages 213-219Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bcmd.2013.07.006
Keywords
Primitive erythropoiesis; Transgenic mice; Mammalian embryo; Yolk sac; Fetal liver; Erythroid differentiation
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Funding
- National Institutes of Health [RO1 HL62248, DK52191, EB02209]
- Roche Foundation for Anemia Research [9699367999]
- New York State Department of Health (NYSTEM grant) [N08G-024]
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Erythropoiesis is the process by which progenitors for red blood cells are produced and terminally differentiate. In all vertebrates, two morphologically distinct erythroid lineages (primitive, embryonic, and definitive, fetal/adult) form successively within the yolk sac, fetal liver, and marrow and are essential for normal development. Red blood cells have evolved highly specialized functions in oxygen transport, defense against oxidation, and vascular remodeling. Here we review key features of the ontogeny of red blood cell development in mammals, highlight similarities and differences revealed by genetic and gene expression profiling studies, and discuss methods for identifying erythroid cells at different stages of development and differentiation. (C) 2013 Elsevier Inc All rights reserved.
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