Journal
MYOPAIN-A JOURNAL OF MYOFASCIAL PAIN AND FIBROMYALAGIA
Volume 23, Issue 1-2, Pages 45-51Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/10582452.2013.852151
Keywords
C-reacitve protein; dermatomyositis; erythrocyte sedimentation rate; idiopathic inflammatory myopathy; Jo-1 syndrome; polymyositis; sporadic inclusion myositis
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Objectives: To characterize C-reactive protein [CRP] in polymyositis [PM], dermatomyositis [DM], Jo-1 syndrome [Jo-1] and sporadic inclusion body myositis [sIBM]. Methods: C-reactive protein obtained before the start of immunosuppressive therapy was analyzed retrospectively in 61 therapy naive patients [PM n = 27, DM n = 15, Jo-1 n = 5, sIBM n = 14]. All patients had a diagnosis of idiopathic inflammatory myopathy confirmed by muscle biopsy. Results: C-reactive protein was significantly higher inDM and Jo-1 compared to PM and sIBM [ANOVA p<0.001]. The CRP levels less than twice the upper limit were found in 79% of sIBM patients, 85% of PM patients, 20% Jo-1 of patients, 53% of DM patients. C-reactive protein showed no correlation with creatine kinase and erythrocyte sedimentation rate. Conclusions: The CRP is elevated in a minority of patients with myositis, mostly associated with interstitial lung disease and malignancies.
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