Journal
BLOOD CELLS MOLECULES AND DISEASES
Volume 47, Issue 1, Pages 41-45Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bcmd.2011.04.002
Keywords
Sickle cell disease; Genetic ancestry; Admixture; Genetic association
Categories
Funding
- NIH [R01 HL 87681, R01 HL 068970, R01 AG09029, R01 AG025259]
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The inheritance of genetic disease depends on ancestry that must be considered when interpreting genetic association studies and can provide insights when comparing traits in a population. We compared the genetic profiles of African Americans with sickle cell disease to those of Black Africans and Caucasian populations of European descent and found that they are less genetically admixed than other African Americans and have an ancestry similar to Yorubans, Mandenkas and Bantu. (C) 2011 Elsevier Inc. All rights reserved.
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