Journal
HIV AIDS-RESEARCH AND PALLIATIVE CARE
Volume 7, Issue -, Pages 95-104Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/HIV.S79956
Keywords
off-target; side effect; glucose transporter-4; proteasome
Categories
Funding
- Hunan Provincial Science and Technology Project of China [2014SK3009]
- Scientific Research Foundation of Hunan Provincial Department of Health [B2013-002]
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Highly active antiretroviral therapy (HAART) is recognized as the most effective treatment method for AIDS, and protease inhibitors play a very important role in HAART. However, poor bioavailability and unbearable toxicity are their common disadvantages. Thus, the development of safer and potentially promising protease inhibitors is eagerly needed. In this review, we introduced the chemical characteristics and associated side effects of HIV protease inhibitors, as well as the possible off-target mechanisms causing the side effects. From the chemical structures of HIV protease inhibitors and their possible off-target molecules, we could obtain hints for optimizing the molecular selectivity of the inhibitors, to provide help in the design of new compounds with enhanced bioavailability and reduced side effects.
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