Journal
NEUROBIOLOGY OF STRESS
Volume 1, Issue -, Pages 66-79Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ynstr.2014.09.004
Keywords
Resilience; Stress; Depression; Anxiety; Neuroimmune; ]Plasticity
Categories
Funding
- US National Institute of Mental Health [R01 MH090264, R01 MH104559, R21 MH099562, F31 MH105217, T32 MH087004, T32 MH096678]
- Janssen/IMHRO Rising Star Award
- NATIONAL INSTITUTE OF MENTAL HEALTH [R21MH099562, P50MH096890, R01MH090264, T32MH087004, R01MH104559, F31MH105217] Funding Source: NIH RePORTER
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Viable new treatments for depression and anxiety have been slow to emerge, likely owing to the complex and incompletely understood etiology of these disorders. A budding area of research with great therapeutic promise involves the study of resilience, the adaptive maintenance of normal physiology and behavior despite exposure to marked psychological stress. This phenomenon, documented in both humans and animal models, involves coordinated biological mechanisms in numerous bodily systems, both peripheral and central. In this review, we provide an overview of resilience mechanisms throughout the body, discussing current research in animal models investigating the roles of the neuroendocrine, immune, and central nervous systems in behavioral resilience to stress. (C) 2014 The Authors. Published by Elsevier Inc.
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