Journal
NPJ SCHIZOPHRENIA
Volume 1, Issue -, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/npjschz.2015.13
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Funding
- Geestkracht program of the Dutch Health Research Council (ZON-MW) [10-000-1001]
- Lundbeck
- AstraZeneca
- Eli Lilly
- Janssen Cilag
- Amsterdam: Academic Psychiatric Centre of the Academic Medical Centre
- Amsterdam: GGZ Ingeest
- Amsterdam: Arkin
- Amsterdam: Dijk en Duin
- Amsterdam: GGZ Rivierduinen
- Amsterdam: Erasmus Medical Centre
- Amsterdam: GGZ Noord Holland Noord
- Maastricht: Maastricht University Medical Centre
- Maastricht: GGZ Eindhoven en de kempen
- Maastricht: GGZ Breburg
- Maastricht: GGZ Oost-Brabant
- Maastricht: Vincent van Gogh voor Geestelijke Gezondheid
- Maastricht: Mondriaan Zorggroep
- Maastricht: Prins Clauscentrum Sittard
- Maastricht: RIAGG Roermond
- Maastricht: Universitair Centrum Sint-Jozef Kortenberg
- Maastricht: CAPRI University of Antwerp
- Maastricht: PC Ziekeren SintTruiden
- Maastricht: PZ Sancta Maria Sint-Truiden
- Maastricht: GGZ Overpelt
- Maastricht: OPZ Rekem
- Groningen: University Medical Centre Groningen
- Groningen: Lentis
- Groningen: GGZ Friesland
- Groningen: GGZ Drenthe
- Groningen: Dimence
- Groningen: Mediant
- Groningen: GGNet Warnsveld
- Groningen: Yulius Dordrecht
- Groningen: Parnassia psycho-medical centre (The Hague)
- Utrecht: University Medical Centre Utrecht
- Utrecht: Altrecht
- Utrecht: GGZ Centraal
- Utrecht: Riagg Amersfoort
- Utrecht: Delta
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BACKGROUND: An increased prevalence of autoantibodies has been found in patients with schizophrenia, suggesting a role for autoimmunity in schizophrenia pathogenesis. METHODS: We examined the presence of antinuclear antibodies (ANAs), with further determination of specific antibodies, in 368 patients with a schizophrenia spectrum disorder and 283 healthy controls. RESULTS: No significant difference in prevalence of ANAs between patients (8%) and controls (11%) was found. CONCLUSION: We did not find an association between ANAs and schizophrenia spectrum disorders. We discuss potential reasons for the discrepancy with some previous studies, such as inclusion of patients using chlorpromazine, which can induce ANAs.
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