Journal
BLOOD
Volume 123, Issue 20, Pages 3166-3174Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2013-11-540526
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Funding
- British Heart Foundation [PG/10/88/28628]
- British Heart Foundation [PG/13/42/30309, PG/10/88/28628] Funding Source: researchfish
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Bacterial adhesion to platelets is mediated via a range of strain-specific bacterial surface proteins that bind to a variety of platelet receptors. It is unclear how these interactions lead to platelet activation. We demonstrate a critical role for the immune receptor Fc gamma RIIA, alpha IIb beta 3, and Src and Syk tyrosine kinases in platelet activation by Staphylococcus aureus, Streptococcus sanguinis, Streptococcus gordonii, Streptococcus oralis, and Streptococcus pneumoniae. Fc gamma RIIA activation is dependent on immunoglobulin G (IgG) and alpha IIb beta 3 engagement. Moreover, feedback agonists adenosine 5'-diphosphate and thromboxane A(2) are mandatory for platelet aggregation. Additionally, platelet factor 4 (PF4) binds to bacteria and reduces the lag time for aggregation, and gray platelet syndromea-granule-deficient platelets do not aggregate to 4 of 5 bacterial strains. We propose that Fc gamma RIIA-mediated activation is a common response mechanism used against a wide range of bacteria, and that release of secondary mediators and PF4 serve as a positive feedback mechanism for activation through an IgG-dependent pathway.
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