Journal
BLOOD
Volume 124, Issue 2, Pages 184-187Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2014-03-562538
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Funding
- National Institutes of Health, National Cancer Institute [R01CA177909]
- Ovarian Cancer Research Fund Program Project Development grant
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Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feedback loop may be operative between platelets and tumor cells, with reciprocal interactions between tumor growth/metastasis and thrombocytosis/platelet activation. Specific molecular pathways have been identified in which tumors can stimulate platelet production and activation; activated platelets can, in turn, promote tumor growth and metastasis. Taken together, these findings provide exciting new potential targets for therapeutic intervention.
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