Related references
Note: Only part of the references are listed.The multiple layers of non-genetic regulation of PTEN tumour suppressor activity
Nadia C. Correia et al.
EUROPEAN JOURNAL OF CANCER (2014)
An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions
E. Clappier et al.
LEUKEMIA (2014)
RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia
Elli Papaemmanuil et al.
NATURE GENETICS (2014)
Breakpoint sites disclose the role of the V(D)J recombination machinery in the formation of T-cell receptor (TCR) and non-TCR associated aberrations in T-cell acute lymphoblastic leukemia
Nicole S. D. Larmonie et al.
HAEMATOLOGICA (2013)
NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia
Obul R. Bandapalli et al.
HAEMATOLOGICA (2013)
Toward a NOTCH1/FBXW7/RAS/PTEN-Based Oncogenetic Risk Classification of Adult T-Cell Acute Lymphoblastic Leukemia: A Group for Research in Adult Acute Lymphoblastic Leukemia Study
Amelie Trinquand et al.
JOURNAL OF CLINICAL ONCOLOGY (2013)
Extensive molecular mapping of TCRα/δ- and TCRβ-involved chromosomal translocations reveals distinct mechanisms of oncogene activation in T-ALL
Sandrine Le Noir et al.
BLOOD (2012)
The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia
Linda Zuurbier et al.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2012)
The Origin and Nature of Tightly Clustered BTG1 Deletions in Precursor B-Cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution
Esme Waanders et al.
PLOS GENETICS (2012)
ETV6/RUNX1-positive relapses evolve from an ancestral clone and frequently acquire deletions of genes implicated in glucocorticoid signaling
Lilian Kuster et al.
BLOOD (2011)
Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia
Irene Homminga et al.
CANCER CELL (2011)
Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse
Emmanuelle Clappier et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias
Chen Shochat et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Genetic variegation of clonal architecture and propagating cells in leukaemia
Kristina Anderson et al.
NATURE (2011)
A continuum model for tumour suppression
Alice H. Berger et al.
NATURE (2011)
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia
Priscila P. Zenatti et al.
NATURE GENETICS (2011)
Genetic rearrangements in relation to immunophenotype and outcome in T-cell acute lymphoblastic leukaemia
Jules P. P. Meijerink
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2010)
Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1
Todd D. Ashworth et al.
BLOOD (2010)
Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemia
P. Y. Jotta et al.
LEUKEMIA (2010)
Cooperative study group for childhood acute lymphoblastic leukaemia (COALL): long-term results of trials 82,85,89,92 and 97
G. Escherich et al.
LEUKEMIA (2010)
NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols
L. Zuurbier et al.
LEUKEMIA (2010)
Subtle variations in Pten dose determine cancer susceptibility
Andrea Alimonti et al.
NATURE GENETICS (2010)
Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways
Suzzette M. Arnal et al.
NUCLEIC ACIDS RESEARCH (2010)
Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMAALWP)
Ilaria Iacobucci et al.
BLOOD (2009)
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia
Alejandro Gutierrez et al.
BLOOD (2009)
Different molecular mechanisms causing 9p21 deletions in acute lymphoblastic leukemia of childhood
Francesca Novara et al.
HUMAN GENETICS (2009)
Dexamethasone-based therapy for childhood acute lymphoblastic leukaemia: results of the prospective Dutch Childhood Oncology Group (DCOG) protocol ALL-9 (1997-2004)
Anjo J. Veerman et al.
LANCET ONCOLOGY (2009)
The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group
A. Larson Gedman et al.
LEUKEMIA (2009)
Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia
Jun J. Yang et al.
BLOOD (2008)
NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL
Maria Luisa Sulis et al.
BLOOD (2008)
The role of the PTEN/AKT pathway in NOTCH1-induced leukemia
Teresa Palomero et al.
CELL CYCLE (2008)
PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability
Ana Silva et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
Charles G. Mullighan et al.
NATURE (2008)
Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia
Charles G. Mullighan et al.
SCIENCE (2008)
Multiple, conserved cryptic recombination signals in VH gene segments:: detection of cleavage products only in pro-B cells
Marco Davila et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
Teresa Palomero et al.
NATURE MEDICINE (2007)
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors
Jennifer O'Neil et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
Benjamin J. Thompson et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Different chromosomal breakpoints impact the level of LMO2 expression in T-ALL
Willem A. Dik et al.
BLOOD (2007)
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
Richard S. Maser et al.
NATURE (2007)
The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling
Alena Malyukova et al.
CANCER RESEARCH (2007)
Drug therapy - Treatment of acute lymphoblastic leukemia
CH Pui et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Homozygous deletions of CDKN2A caused by alternative mechanisms in various human cancer cell lines
S Raschke et al.
GENES CHROMOSOMES & CANCER (2005)
Involvement of illegitimate V(D)J recombination or microhomology-mediated nonhomologous end-joining in the formation of intragenic deletions of the Notch1 gene in mouse thymic lymphomas
H Tsuji et al.
CANCER RESEARCH (2004)
Involvement of V(D)J recombinase in the generation of intragenic deletions in the Rit1/Bcl11b tumor suppressor gene in γ-ray-induced thymic lymphomas and in normal thymus of the mouse
J Sakata et al.
CARCINOGENESIS (2004)
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
AP Weng et al.
SCIENCE (2004)
Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL
R Marculescu et al.
NATURE GENETICS (2003)
Prevalent involvement of illegitimate V(D)J recombination in chromosome 9p21 deletions in lymphoid leukemia
Y Kitagawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
BFM-oriented treatment for children with acute lymphoblastic leukemia without cranial irradiation and treatment reduction for standard risk patients:: results of DCLSG protocol ALL-8 (1991-1996)
WA Kamps et al.
LEUKEMIA (2002)
V(D)J-mediated translocations in lymphoid neoplasms: A functional assessment of genomic instability by cryptic sites
R Marculescu et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
Alternative end-joining in follicular lymphomas' t(14;18) translocation
R Marculescu et al.
LEUKEMIA (2002)
Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints
SC Raghavan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
How to make ends meet in V(D)J recombination
U Grawunder et al.
CURRENT OPINION IN IMMUNOLOGY (2001)