Journal
JOURNAL OF EXPERIMENTAL NEUROSCIENCE
Volume 9, Issue -, Pages 43-50Publisher
SAGE PUBLICATIONS LTD
DOI: 10.4137/JEN.S25515
Keywords
tau; tauopathy; glial tau pathology; functional consequences; neurodegeneration; astrocytes; oligodendrocytes; microglia
Categories
Ask authors/readers for more resources
Tauopathies are a class of neurodegenerative diseases characterized by the presence of hyperphosphorylated and aggregated tau pathology in neuronal and glial cells. Though the ratio of neuronal and glial tau aggregates varies across diseases, glial tau aggregates can populate the same degenerating brain regions as neuronal tau aggregates. While much is known about the deleterious consequences of tau pathology in neurons, the relative contribution of glial tau pathology to these diseases is less clear. Recent studies using a number of model systems implicate glial tau pathology in contributing to tauopathy pathogenesis. This review aims to highlight the functional consequences of tau overexpression in glial cells and explore the potential contribution of glial tau pathology in the pathogenesis of neurodegenerative tauopathies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available