Journal
JOURNAL OF EXPERIMENTAL NEUROSCIENCE
Volume 9, Issue -, Pages 11-24Publisher
SAGE PUBLICATIONS LTD
DOI: 10.4137/JEN.S25472
Keywords
AMPA receptors; desensitization; development; glutamate transporters; nucleus magnocellularis; short-term synaptic depression
Categories
Funding
- National Research Service Award from the National Institute on Deafness [F32 DC010307]
- U.S. Public Health Service
- Hugh Knowles Hearing Research Center
- School of Communication, Northwestern University
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [F32DC010307] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Defined as reduced neural responses during high rates of activity, synaptic depression is a form of short-term plasticity important for the temporal filtering of sound. In the avian cochlear nucleus magnocellularis (NM), an auditory brainstem structure, mechanisms regulating short-term synaptic depression include pre-, post-, and extrasynaptic factors. Using varied paired-pulse stimulus intervals, we found that the time course of synaptic depression lasts up to four seconds at late-developing NM synapses. Synaptic depression was largely reliant on exogenous Ca2+-dependent probability of presynaptic neurotransmitter release, and to a lesser extent, on the desensitization of postsynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPA-R). Interestingly, although extrasynaptic glutamate clearance did not play a significant role in regulating synaptic depression, blocking glutamate clearance at early-developing synapses altered synaptic dynamics, changing responses from depression to facilitation. These results suggest a developmental shift in the relative reliance on pre-, post-, and extrasynaptic factors in regulating short-term synaptic plasticity in NM.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available