Journal
AIMS GENETICS
Volume 2, Issue 1, Pages 54-69Publisher
AMER INST MATHEMATICAL SCIENCES-AIMS
DOI: 10.3934/genet.2015.1.54
Keywords
Drosophila; imaginal discs; apoptosis; caspase; cancer
Categories
Funding
- National Institutes of Health [RO1 GM106317]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM106317] Funding Source: NIH RePORTER
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Drosophila melanogaster remains a foremost genetic model to study basic cell biological processes in the context of multi-cellular development. In such context, the behavior of one cell can influence another. Non-autonomous signaling among cells occurs throughout metazoan development and disease, and is too vast to be covered by a single review. I will focus here on non-autonomous signaling events that occur in response to cell death in the larval epithelia and affect the life-death decision of surviving cells. I will summarize the use of Drosophila to study cell death-induced proliferation, apoptosis-induced apoptosis, and apoptosis-induced survival signaling. Key insights from Drosophila will be discussed in the context of analogous processes in mammalian development and cancer biology.
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