Journal
RARE DISEASES
Volume 3, Issue 1, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21675511.2015.1045169
Keywords
developmental disorders; genotype-phenotype correlation; genetic backgrounds; mouse models; modifiers; Noonan Syndrome; Rasopathies; Ras oncogenes
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Funding
- Fondo de Investigacion Sanitaria [PI042124, PI08-1623, PI11-02529]
- Autonomous Community of Madrid [GR/SAL/0349/2004]
- Fundacion Ramon Areces [FRA 01-09-001]
- Instituto de Salud Carlos III
- Spanish Ministry of Economy and Competitiveness
- COFUND scheme of the Seventh Framework Program of the European Union [291820]
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Noonan syndrome (NS) is an autosomal dominant genetic disorder characterized by short stature, craniofacial dysmorphism, and congenital heart defects. A significant fraction of NS-patients also develop myeloproliferative disorders. The penetrance of these defects varies considerably among patients. In this study, we have examined the effect of 2 genetic backgrounds (C57BL/6J. OlaHsd and 129S2/SvPasCrl) on the phenotypes displayed by a mouse model of NS induced by germline expression of the mutated K-Ras(V14I) allele, one of the most frequent NS-KRAS mutations. Our results suggest the presence of genetic modifiers associated to the genetic background that are essential for heart development and function at early stages of postnatal life as well as in the severity of the haematopoietic alterations.
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