Journal
TRANSCRIPTION-AUSTIN
Volume 6, Issue 4, Pages 61-64Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21541264.2015.1071301
Keywords
biogenesis; circular RNA; exon-intron circular RNA; microRNA sponge; transcriptional regulation
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Funding
- National Basic Research Program of China [2011CBA01103, 2015CB943000]
- National Natural Science Foundation of China [31471225, 81171074, 91232702]
- CAS [KJZD-EW-L01-2]
- Fundamental Research Funds for the Central Universities [WK2070000034]
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Circular RNAs (circRNAs) are a large family of noncoding RNAs (ncRNAs) found in metazoans. Systematic studies of circRNAs have just begun. Here, we discuss circRNA biogenesis and functions with a focus on studies indicating great diversification of circRNAs. We highlight the recent identification of a special subtype of circRNAs, called EIciRNAs, and their role in transcriptional regulation. New insights on RNA-RNA interaction and other features associated with circRNA biology are also discussed.
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