Journal
BLOOD
Volume 120, Issue 7, Pages 1466-1469Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2012-02-408542
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Funding
- Institut National du Cancer
- Programme Hospitalier de Recherche Clinique
- Fondation pour la recherche Medicale (FRM)
- Association pour la Recherche contre le Cancer
- FRM
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Inactivating mutations of the Ten-Eleven Translocation 2 (TET2) gene were first identified in myeloid malignancies and more recently in peripheral T-cell lymphomas (PTCLs). In the present study, we investigated the presence of TET2 coding sequence mutations and their clinical relevance in a large cohort of 190 PTCL patients. TET2 mutations were identified in 40 of 86 (47%) cases of angioimmunoblastic T-cell lymphoma (AITL) and in 22 of 58 (38%) cases of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), but were absent in all other PTCL entities, with the exception of 2 of 10 cases of enteropathy-associated T-cell lymphoma. Among PTCL-NOS, a heterogeneous group of lymphoma-comprising cases likely to derive from Th follicular (T-FH) cells similarly to AITL, TET2 mutations were more frequent when PTCL-NOS expressed T-FH markers and/or had features reminiscent of AITL (58% vs 24%, P = .01). In the AITL and PTCL-NOS sub-groups, TET2 mutations were associated with advanced-stage disease, thrombocytopenia, high International Prognostic Index scores, and a shorter progression-free survival. (Blood. 2012;120(7):1466-1469)
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