Journal
BLOOD
Volume 120, Issue 20, Pages 4246-4255Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2012-02-413260
Keywords
-
Categories
Funding
- Leukemia & Lymphoma Society [08023, 09023]
- Stem Cell Transplant Trust Fund at University Hospital Birmingham (Birmingham, United Kingdom)
- Medical Research Council [G9818340B] Funding Source: researchfish
Ask authors/readers for more resources
Chemokines regulate the migration of hemopoietic cells and play an important role in the pathogenesis of many immunemediated diseases. Intradermal recruitment of CD8(+) T cells by CXCL10 is a central feature of the pathogenesis of cutaneous acute GVHD (aGVHD), but very little is known about the pathogenesis of chronic GVHD (cGVHD). Serum concentrations of the 3 CXCR3-binding chemokines, CXCL9, CXCL10, and CXCL11, were found to be markedly increased in patients with active cGVHD of the skin (n = 8). An 80% decrease in CD4(+) cells expressing CXCR3 was seen in the blood of these patients (n = 5), whereas CD4(+) cells were increased in tissue biopsies and were clustered around the central arterioles of the dermis. The well-documented increase in expression of CXCL10 in aGVHD therefore diversifies in cGVHD to include additional members of the CXCR3-binding family and leads to preferential recruitment of CD4(+) T cells. These observations reveal a central role for chemokine-mediated recruitment of CXCR3(+) T cells in cGVHD. (Blood. 2012; 120(20): 4246-4255)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available