Journal
BLOOD
Volume 120, Issue 12, Pages 2450-2453Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2011-08-371567
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Funding
- Norwegian Cancer Society
- Norwegian Research Council
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In multiple myeloma, c-MYC is activated and contributes to the malignant phenotype. Targeting MYC by short hairpin RNA induced cell death in myeloma cell lines; however, cell lines are generated from samples taken in advanced stages of the disease and may not reflect patient cells adequately. In this study, we used the selective small molecule inhibitor of MYC-MAX heterodimerization, 10058-F4, on myeloma cell lines as well as primary myeloma cells, and we show that inhibition of c-MYC activity efficiently induces myeloma cell death. Moreover, in cocultures of cell lines with bone marrow stromal cells from myeloma patients, the inhibitor still induces apoptosis. Our results provide further evidence that myeloma cells are addicted to c-MYC activity and that c-MYC is a promising therapeutic target in multiple myeloma. (Blood. 2012;120(12):2450-2453)
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