Journal
BLOOD
Volume 120, Issue 24, Pages 4869-4872Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2012-06-438598
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Funding
- Baylor College of Medicine University of Texas MD Anderson Cancer Centers [P50 CA083639, U54 CA151668, CA101642]
- Foundation for Women's Cancer/Ovarian Cancer National Alliance Ovarian Cancer Research Grant
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Platelets promote metastasis and angiogenesis, but their effect on tumor cell growth is uncertain. Here we report a direct proliferative effect of platelets on cancer cells both in vitro and in vivo. Incubation of platelets with ovarian cancer cells from murine (ID8 and 2C6) or human (SKOV3 and OVCAR5) origin increased cell proliferation. The proliferative effect of platelets was not dependent on direct contact with cancer cells, and preincubation of platelets with blocking antibodies against platelet adhesion molecules did not alter their effect on cancer cells. The proliferative effect of platelets was reduced by fixing platelets with paraformaldehyde, preincubating platelets with a TGF-beta 1-blocking antibody, or reducing expression of TGF-beta R1 receptor on cancer cells with siRNA. Infusing platelets into mice with orthotopic ovarian tumors significantly increased the proliferation indices in these tumors. Ovarian cancer patients with thrombocytosis had higher tumor proliferation indices compared with patients with normal platelet counts. (Blood. 2012;120(24):4869-4872)
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